Daunorubicin in acute leukaemia

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Daunorubicin in acute leukaemia.

Daunorubicin has been used in the treatment of six cases of acute lymphoblastic and thirteen cases of acute myeloblastic and mono-myeloblastic leukaemia. Complete remissions were obtained in eight patients, three with acute lymphoblastic leukaemia and five with acute myeloblastic leukaemia. Marrow aplasia makes the drug difficult to administer, but no patients died from this cause, in this seri...

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Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...

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Dacryocystitis in Acute Leukaemia.

LEUKAEMIC infiltration of the lacrimal sac is rare (Duke-Elder, 1952) and dacryocystitis due to leukaemic involvement of the sac has seldom been reported (Stokes, 1938; Busina, 1950). The number of cases recorded is increased when the reports of Sulzer and Duclos (1906), Pascheff (1927), and Weve (1928) are considered, but these authors described lymphomata of the sac without the typical blood ...

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Moniliasis in acute leukaemia.

The prolonged use of antibiotics, cortisone, or a combination of both has resulted in an increase in infections with monilia. With the recent advances in the treatment of acute leukaemia to include anti-metabolites, corticoids, and antibiotics, an increased incidence of monilial infections might be expected. This paper reports the clinical and necropsy findings in five cases of acute leukaemia ...

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Current concepts underlying the treatment of the acute leukaemias are presented. Improved drug regimens and ancillary services have been developed and their role in the management of acute leukaemia is reviewed.

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1970

ISSN: 0032-5473

DOI: 10.1136/pgmj.46.535.272